Breast cancer ixabepilone xeloda

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Skip to search form Skip to main content. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. View on PubMed.

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This document addresses ixabepilone Ixempraa non-taxane chemotherapy agent which blocks cells in the mitotic phase of the cell division cycle, leading to cell death. Ixabepilone is used alone or in combination with oral capecitabine to treat breast cancer which has been previously treated with other therapies. Use of ixabepilone is considered medically necessary for the treatment of metastatic or locally advanced breast cancer for any of the following indications:.

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Cytotoxic chemotherapy is one of the cornerstones for the treatment of metastatic breast cancer MBC. Drug resistance remains the most common cause of treatment failure; in particular, resistance to anthracyclines and taxanes hinders the management of MBC. One result of research into novel cytotoxics has been the development of a new class of drugs known as the epothilones.

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Anthracyclines and taxanes have long been described as the most active classes of chemotherapy against breast cancer. With incorporation of these agents into early stage breast cancer treatment regimens, researchers have conducted extensive investigation in pursuit of novel cytotoxic agents that have antitumor activity in anthracycline- and taxane-resistant disease. Capecitabine had been the only FDA-approved agent for the treatment of anthracycline- and taxane-resistant metastatic breast cancer.

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By Caroline Helwick July 25, Advertisement. Seidman, MDand colleagues from several cancer centers. These patients are in need of more options that allow them to maintain their quality of life while on treatment.

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Capecitabine - Substance Summary. Capecitabine Xeloda. Toggle navigation.

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Perez, Joseph A. Patients with metastatic breast cancer MBC previously treated with anthracyclines and taxanes often have decreased performance status secondary to extensive tumor involvement. Here, we report the pooled analysis of efficacy and safety data from two similarly designed phase III studies to provide a more precise estimate of benefit of ixabepilone plus capecitabine in MBC patients with Karnofsky's performance status KPS In patients with reduced performance status KPSixabepilone plus capecitabine was associated with improvements in OS median:

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Breast cancer causes approximately 40, deaths annually in the United States. Currently, treatment for MBC is palliative and involves balancing improvement in cancer symptoms and delay of progression against side effects of therapy. It was later approved in combination with docetaxel after the combination resulted in improved overall survival OS when compared with docetaxel alone.

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Disclosure: L. No other potential conflicts of interest were reported by the author, planners, reviewers, or staff managers of this article. Evaluate the clinical significance of the lower susceptibility of epothilones to key mechanisms of drug resistance. Explain the key mechanisms of drug resistance to which epothilones display lower susceptibility.

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